Hyperthermia-induced Cell Death

Hyperthermia has been shown to have promising antitumor effects for various types of malignant tumors. It is one the most potent adjuvant cancer therapy when combined with radiotherapy and chemotherapy. The range hyperthermia temperature (40-45 ℃) induces cell killing depending on period treatment. Although kinetics inactivation by heat using clonogenic assay well studied, molecular mechanism heat-induced death still unclear. Till now only two distinct forms death, apoptosis necrosis, induced can be recognized morphologically. However, in current classification twelve described. objective this review overview based recent classification, summarize each type, evaluate clinical significance, discuss future directions research.